Pharmacotherapy

The author proposes, as disease for the study of drugs activity on vestibular compensation mechanisms in man, a peripheral labyrinthine disease without spontaneous nystagmus of type II or III. He evaluates the state of compensation by the evolution of static posturography parameters and by the score of Norre’s VHT (vestibular habituation training) during an observation […]

For Meniere`s Disease (M.D.) patients, we are using Betahistin as standard therapy & additionally Urea or Acetazolamide for the attack periods, with good results. But in severe cases of invalidating M.D. causing extensive vertigo, we are using since 6 years labyrinth perfusion by a solution of Gentamycine and Betamethazon. Methods: After insertion of a large […]

In this report, we summarize our clinical experience with intratympanic dexamethasone treatment (IDT) for control of tinnitus.

In a randomized, double-blind clinical study, we evaluated the efficacy and tolerability of the fixed combination of cinnarizine, 20 mg, and dimenhydrinate, 40 mg (Arlevert [ARL]) in comparison to betahistine dimesylate (12 mg) in 82 patients suffering from Ménière’s disease for at least 3 months and showing the characteristic triad of symptoms (paroxysmal vertigo attacks, […]

During the last half century, medical developments have expedited an increase of expectation of life, all over the world. This extension of life has made that some pathologies that in former years were considered of low prevalence, nowadays they have become top priority for public health.

Transtympanic gentamicin administration has become a popular modality in the treatment of Ménière’s disease. This modality and other inner-ear medical therapy are gaining increased clinical and scientific attention.

Our goal was to attempt to establish neuropharmacological tinnitus control (i.e., relief) with medication directed to restoration of a deficiency in the g-aminobutyric acid – benzodiazepine – chloride receptor in tinnitus patients with a diagnosis of a predominantly central type tinnitus.

At the ear, nose, and throat clinic of the Third Medical Faculty at Charles University and at the Psychiatry Department of the Institute for Further Education of Physicians in Prague, we examined 25 patients with tinnitus accompanied by psychiatric disturbances and followed them up for at least 6 months.

We carried out a retrospective survey of 25 years of clinical experience with the use of clonazepam as a vestibular and tinnitus suppressant in the pharmacological treatment of vestibular or cochleovestibular disorders due to different causes.

THE ROLE OF THE VESTIBULAR SYSTEM IS TO INTEGRATE POLISENSORIAL CUES AND PROVIDE A CONTINUOS AND PRECISE REPRESENTATION EITHER OF THE BODY SHAPE (SEGMENTAL BODY ORIENTATION, THAT TO SAY PERCEPTION OF THE RECIPROCAL POSITION OF BODY SEGMENTS ) OR THE ORIENTATION OF THE BODY INTO THE ENVIRONMENT (SPATIAL ORIENTATION). MELATONIN IS A NATURAL HORMONE SECRETED […]